Serious urinary tract infections can occur in Talk to your healthcare provider about what you can do to prevent dehydration, including how much fluid you should drink on a daily basis, and if you reduce the amount of food or liquid you drink, if you are sick or cannot eat, or start to lose liquids from your body from vomiting, diarrhea or being in the sun too long. You may be at higher risk of dehydration if you have kidney problems, are 65 years of age or older, are on a low salt diet, or take medicines to lower your blood pressure, including water pills (diuretics). Sudden worsening of kidney function has happened in people who are taking SYNJARDY or SYNJARDY XR. Dehydration may cause you to feel dizzy, faint, light‐headed, or weak, especially when you stand up. SYNJARDY or SYNJARDY XR can cause some people to become dehydrated (the loss of body water and salt). Stop taking SYNJARDY or SYNJARDY XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms, and, if possible, check for ketones in your urine:ĭehydration. Ketoacidosis has also happened in people with diabetes who were sick or who had surgery during treatment with SYNJARDY or SYNJARDY XR. Ketoacidosis occurs in people with type 1 diabetes and can also in people with type 2 diabetes taking SYNJARDY or SYNJARDY XR, even if blood sugar is less than 250 mg/dL. Ketoacidosis is a serious condition, which needs to be treated in the hospital. Ketoacidosis (increased ketones in your blood or urine). SYNJARDY or SYNJARDY XR may cause serious side effects, including: are allergic to empagliflozin (JARDIANCE), metformin, or any of the ingredients in SYNJARDY or SYNJARDY XR.have a condition called metabolic acidosis or diabetic ketoacidosis (increased ketones in the blood or urine).have severe kidney problems, end stage renal disease, or are on dialysis.You have a higher chance of getting lactic acidosis with SYNJARDY or SYNJARDY XR if you: have moderate to severe kidney problems have liver problems drink a lot of alcohol (very often or short term “binge” drinking) get dehydrated (lose a large amount of body fluids) have certain x-ray tests with injectable dyes or contrast agents have surgery or other procedure for which you need to restrict the amount of food and liquid you eat and drink have congestive heart failure have a heart attack, severe infection, or stroke, or are 65 years of age or older.ĭo not take SYNJARDY or SYNJARDY XR if you: Stop taking SYNJARDY and SYNJARDY XR and call your healthcare provider right away or go to the nearest hospital emergency room if you get any of the following symptoms of lactic acidosis: feel very weak and tired have unusual (not normal) muscle pain have trouble breathing have unexplained stomach or intestinal problems with nausea and vomiting, or diarrhea have unusual sleepiness or sleep longer than usual feel cold, especially in your arms and legs feel dizzy or lightheaded have a slow or irregular heartbeat. Lactic acidosis isĪ medical emergency and must be treated in a hospital. SYNJARDY XR, can cause lactic acidosis, a rare but serious condition that can cause death. Metformin hydrochloride, one of the medicines in SYNJARDY and Lactic acidosis (a build-up of lactic acid in the blood). IMPORTANT SAFETY INFORMATION SYNJARDY and SYNJARDY XR can cause serious side effects, including:
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